Sertraline
What is Sertraline?
Sertraline is an antidepressant medication belonging to a group called selective serotonin reuptake inhibitors (SSRIs). It is one of the most commonly prescribed antidepressants in the UK and is recommended by NICE for depression, generalised anxiety disorder (GAD), panic disorder, OCD, and PTSD.
How It Works
Sertraline increases the level of serotonin in the brain. Serotonin is a neurotransmitter that plays a key role in mood regulation, sleep, and appetite. By blocking the reuptake of serotonin, sertraline makes more serotonin available in the brain.
How Long Does It Take to Work?
Most people notice an improvement in symptoms within 4-6 weeks, but it can take up to 12 weeks to feel the full benefit. Do not stop taking it if you do not notice an improvement immediately.
Common Side Effects
Side effects are usually mild and improve after the first few weeks:
- Nausea, diarrhoea or indigestion
- Headache
- Dizziness
- Dry mouth
- Difficulty sleeping
- Feeling shaky or agitated
- Reduced sex drive or difficulty reaching orgasm
Important Information
- Do not stop taking sertraline suddenly — the dose should be reduced gradually to avoid withdrawal effects
- In the first few weeks, some people (especially young people under 25) may notice increased suicidal thoughts — seek help immediately if this happens
- Avoid alcohol while taking sertraline
- It is generally safe to take sertraline during pregnancy if the benefits outweigh the risks — always discuss with your doctor