NHS-sourced information. Always read the patient information leaflet (PIL) and speak to your pharmacist or GP before starting, stopping or changing this medication.
Sertraline is an antidepressant medication belonging to a group called selective serotonin reuptake inhibitors (SSRIs). It is one of the most commonly prescribed antidepressants in the UK and is recommended by NICE for depression, generalised anxiety disorder (GAD), panic disorder, OCD, and PTSD.
Sertraline increases the level of serotonin in the brain. Serotonin is a neurotransmitter that plays a key role in mood regulation, sleep, and appetite. By blocking the reuptake of serotonin, sertraline makes more serotonin available in the brain.
Most people notice an improvement in symptoms within 4-6 weeks, but it can take up to 12 weeks to feel the full benefit. Do not stop taking it if you do not notice an improvement immediately.
Side effects are usually mild and improve after the first few weeks:
All medications can cause side effects, though not everyone gets them. The list below shows the most commonly reported effects. Contact your GP or pharmacist if you are concerned.
Always tell your doctor and pharmacist about all medicines you take, including vitamins, supplements, and over-the-counter products. Some interactions can increase side effects or reduce how well a medicine works.