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Clinical Trial ยท PHASE2 ยท Recruiting

A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.

03 April 2026 NCT07222917 ClinicalTrials.gov โ†—
✅ This trial is currently recruiting volunteers
If you think you might be eligible, speak to your GP or specialist about this trial before applying.
Status
Recruiting
Phase
PHASE2
Participants
ALL
Age Range
18 Years+

About This Trial

International, Multicenter and Double-Blind study. The purpose is to measure the effect of baxdrostat in combination with dapagliflozin compared with baxdrostat/placebo on albuminuria, as well as safety, in participants with chronic kidney disease and high blood pressure.

Who Can Join?

Inclusion Criteria: 1. Participants of any sex and gender must be โ‰ฅ 18 years of age at the time of signing the informed consent. 2. Participants with eGFR โ‰ฅ 30 and < 90 mL/min/1.73 m2 at screening 3. Participants with UACR > 200 mg/g (22.6 mg/mmol) and < 5000 mg/g (565 mg/mmol) at screening 4. Participants with history of HTN and a SBP โ‰ฅ 130 mmHg at screening and โ‰ฅ 120 mmHg at the randomisation visit. 5. Stable and maximum daily tolerated dose of either an ACE inhibitor or an ARB (not both) for at least 4 weeks prior to the screening visit, if not medically contraindicated. 6. Participants with: 1. Serum or plasma potassium โ‰ฅ 3.0 and โ‰ค 4.8 mmol/L if eGFR โ‰ฅ 45 mL/min/1.73 m2. 2. Serum or plasma potassium โ‰ฅ 3.0 and โ‰ค 4.5 mmol/L if eGFR < 45 mL/min/1.73 m2. 7. Contraceptive use should be consistent…

⚠ Always speak to your doctor before applying to any clinical trial.

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