✅ This trial is currently recruiting volunteers
If you think you might be eligible, speak to your GP or specialist about this trial before applying.
Status
Recruiting
Phase
PHASE2
Participants
ALL
Age Range
18 Years+
About This Trial
International, Multicenter and Double-Blind study. The purpose is to measure the effect of baxdrostat in combination with dapagliflozin compared with baxdrostat/placebo on albuminuria, as well as safety, in participants with chronic kidney disease and high blood pressure.
Who Can Join?
Inclusion Criteria: 1. Participants of any sex and gender must be โฅ 18 years of age at the time of signing the informed consent. 2. Participants with eGFR โฅ 30 and < 90 mL/min/1.73 m2 at screening 3. Participants with UACR > 200 mg/g (22.6 mg/mmol) and < 5000 mg/g (565 mg/mmol) at screening 4. Participants with history of HTN and a SBP โฅ 130 mmHg at screening and โฅ 120 mmHg at the randomisation visit. 5. Stable and maximum daily tolerated dose of either an ACE inhibitor or an ARB (not both) for at least 4 weeks prior to the screening visit, if not medically contraindicated. 6. Participants with: 1. Serum or plasma potassium โฅ 3.0 and โค 4.8 mmol/L if eGFR โฅ 45 mL/min/1.73 m2. 2. Serum or plasma potassium โฅ 3.0 and โค 4.5 mmol/L if eGFR < 45 mL/min/1.73 m2. 7. Contraceptive use should be consistent…
⚠ Always speak to your doctor before applying to any clinical trial.