✅ This trial is currently recruiting volunteers
If you think you might be eligible, speak to your GP or specialist about this trial before applying.
Age Range
18 Years – 90 Years
About This Trial
Heart Failure (HF) is a global condition affecting at least 26 million people worldwide. Despite advances in treatment, HF patients continue to experience poor health outcomes. This study aims to improve understanding of the role of blood vessels in people with heart failure.
The study will assess how arterial stiffness (how stiff blood vessels are) and endothelial function (how well the lining of blood vessels functions) change over time and respond to treatments received as part of routine clinical care. Blood vessel function and heart performance will be assessed at three time points:
* At baseline (when Patients are first diagnosed with heart failure).
* After completing 4 ± 2 weeks of heart-failure medicines prescribed to patients as part of their routine clinical care.
* After completion of cardiac rehabilitation program as a part of their routine clinical care.
All assessments are non-invasive.
Who Can Join?
Inclusion Criteria: * Male and female ≥ 18 years old. * Have a confirmed de-novo diagnosis of Heart failure with preserved ejection fraction or Heart failure with reserved ejection fraction. Common HF phenotypes (e.g., hypertension, diabetes, obesity) will be recorded as part of routine baseline data but will not influence recruitment or sampling. . * Have stable Heart failure in the opinion of the investigator. * Have ability, in the opinion of the investigator, to participate in study activities. * Able to provide written informed consent. Exclusion Criteria: * • Inability to provide verbal informed consent. * Presenting with severe symptoms; major co-morbidity or other alternative diagnoses (e.g., malignancy, severe respiratory disease, severe mental health problem/s). * Recent acute coronary syndrome (within 60 days). * Severe physical disability preventing independence. * Severe renal insufficiency. * Pregnancy (Present or planned). * Life expectancy less than 12 months
⚠ Always speak to your doctor before applying to any clinical trial.