Recruiting
PHASE1
Gut & Digestion
A Study to Investigate the Safety and Tolerability of Multiple Study Interventions in Participants With Moderate to Severe Ulcerative Colitis
This study will look at how safe and tolerable different treatments are for adults who have moderate to severe ulcerative colitis (UC). The platform design uses one single…
🏢 GlaxoSmithKline
📅 28 Oct 2026
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Recruiting
PHASE1
Cancer
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
BOLD-100 is an intravenously administered sterile solution containing the ruthenium-based small molecule. BOLD-100 has been shown to preferentially decrease the expression of GRP78 in tumour cells and ER…
🏢 Bold Therapeutics, Inc.
📅 28 Oct 2026
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Recruiting
PHASE1
Cancer
A Study of MGC026 in Participants With Advanced Solid Tumors
The study is designed to understand the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of vobramitamab tavatecan (MGC026) in participants with relapsed or refractory, unresectable, locally advanced…
🏢 MacroGenics
📅 28 Oct 2026
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Recruiting
PHASE2
Lung & Breathing
Phase 2b Efficacy and Safety Study of AERO-007, an Inhaled LABA+LAMA Combination for Nebulization Delivery in COPD Patients
This is a phase 2b, randomized, double-blind, placebo-controlled, dose-ranging,14-day dosing, 2-period crossover study in participants with chronic obstructive pulmonary disease (COPD).
🏢 AeroRx Therapeutics Inc.
📅 28 Oct 2026
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Recruiting
NA
Heart & Circulation
A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under Deep Sedation
Pulsed Field Ablation (PFA) has created a 'paradigm shift' within cardiac electrophysiology and the initial experience demonstrates that PFA is safe, rapid and effective compared to both radiofrequency…
🏢 East Sussex Healthcare NHS Trust
📅 28 Oct 2026
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Recruiting
Heart & Circulation
Cardiovascular Acoustics for Early Disease Detection
There are many types of heart disease. Two of the most common causes are narrowings within the blood vessels that supply the heart (known as coronary artery disease),…
🏢 Cambridge University Hospitals NHS Foundation Trust
📅 28 Oct 2026
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Recruiting
NA
Heart & Circulation
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery…
🏢 Imperial College London
📅 28 Oct 2026
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Recruiting
PHASE3
Cancer
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human…
🏢 Daiichi Sankyo
📅 28 Oct 2026
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Recruiting
PHASE3
Cancer
Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 or 2 Systemic Treatment Regimens
Study CL3-95031-007 (CHONQUER) is a Phase 3, international, multicenter, double-blind, randomized, placebo-controlled study of orally administered ivosidenib. Participants are required to have a histopathological diagnosis consistent with isocitrate…
🏢 Servier Bio-Innovation LLC
📅 28 Oct 2026
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Recruiting
Gut & Digestion
Robotic Inflammatory Bowel Disease Development, Learning and Efficacy Study
To determine if robotic surgery can be performed for inflammatory bowel disease (IBD) patients, to ascertain the optimal robotic set up for multi-quadrant IBD operations and evaluate clinical…
🏢 University Hospitals Coventry and Warwickshire NHS Trust
📅 27 Oct 2026
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Recruiting
Cancer
Treatment Effectiveness in People With axSpA or PsA Starting Treatment With Bimekizumab, Risankizumab, Guselkumab, Upadacitinib, or a TNF Inhibitor
This observational study will target patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) who have started treatment with bimekizumab, upadacitinib, risankizumab, guselkumab, or a tumour necrosis factor-alpha…
🏢 Adelphi Real World
📅 27 Oct 2026
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Recruiting
Brain & Nerves
REAL-MS: Observational Database Study of AHSCT and MS Therapies
Multiple sclerosis (MS) is a condition in which the immune system damages the brain and spinal cord. Treatments called disease-modifying therapies can reduce inflammation and disease activity. For…
🏢 Imperial College London
📅 27 Oct 2026
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Recruiting
Lung & Breathing
Remote Monitoring of Asthma in Children and Young People
The objective of this study is to determine whether healthcare data and remotely collected patient data can accurately predict asthma attacks in children and young people aged 5-17…
🏢 University of Edinburgh
📅 27 Oct 2026
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Recruiting
Lung & Breathing
Comparing Advanced Technologies to Standard Testing for the Diagnosis of Airway Disease in Hospital and Community Settings
Airway disease, such as chronic obstructive pulmonary disease (COPD), is usually diagnosed through breathing tests like spirometry. However, it requires people to blow forcefully into a machine several…
🏢 University Hospital Southampton NHS Foundation Trust
📅 27 Oct 2026
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Recruiting
Cancer
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment
Prostate cancer is now the most common cancer in men in the Western world. In the United Kingdom (UK), there were over 52,000 new cases diagnosed in 2016-2018…
🏢 Institute of Cancer Research, United Kingdom
📅 27 Oct 2026
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Recruiting
PHASE3
Cancer
A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant
Elranatamab is a bispecific antibody: binding of elranatamab to CD3-expressing T-cells and BCMA-expressing multiple myeloma cells causes targeted T-cell-mediated cytotoxicity. The main purpose of the study is to…
🏢 Pfizer
📅 27 Oct 2026
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Recruiting
PHASE1
Diabetes & Weight
A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity
The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ascending doses of WVE-007 when administered subcutaneously (SC) . Part A is a…
🏢 Wave Life Sciences USA, Inc.
📅 26 Oct 2026
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Recruiting
PHASE2
Gut & Digestion
A Study of How the Medicine Called “Etrasimod” Works in Children With the Gut Disease Called Ulcerative Colitis
The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in pediatrics…
🏢 Pfizer
📅 26 Oct 2026
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