✅ This trial is currently recruiting volunteers
If you think you might be eligible, speak to your GP or specialist about this trial before applying.
Age Range
40 Years – 60 Years
About This Trial
This study will explore whether a daily probiotic drink containing Lactobacillus casei Shirota (LcS) can help improve immune function and reduce inflammation in women going through the menopausal transition. Hormonal changes during this stage of life can affect the immune system, gut health, and skin, sometimes leading to increased inflammation or conditions such as eczema, acne or rosacea.
Participants will consume either a low-sugar LcS probiotic drink or a skimmed milk control drink every day for eight weeks. The study will assess markers of immune ageing, inflammation, skin health, wellbeing, and hormone levels. The results will help determine whether a safe, non-hormonal probiotic approach may support immune and skin health during the menopausal transition.
Who Can Join?
Inclusion Criteria: 1. Female, aged 40-60 years. 2. Self-reported or clinician-diagnosed non-infectious, non-autoimmune inflammatory skin condition affecting the face (e.g., rosacea, acne, eczema). 3. Willing and able to consume a daily oral intervention (2x 65 ml probiotic drinks or skimmed milk) for 8 weeks. 4. Willing and able to provide sufficient blood, skin and stool samples at baseline and end-of-study (Week 8). Participants unable to provide adequate blood sample volumes will not be able to start the intervention. 5. Willing and able to provide a photograph of the facial area, with all images anonymised for study purposes. 6. Able to comply with study procedures, including attending clinic visits at KCL. 7. Have access to a refrigerator at home and be able to store the study product(s) safely after collection (i.e., travel time allows safe storage). 8. Capable of providing written informed consent. 9. Have sufficient proficiency in English to complete…
⚠ Always speak to your doctor before applying to any clinical trial.