The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms
25 March 2026
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🅇 This trial is currently recruiting participants in the UK
Speak to your GP or specialist first. They can help you understand if you might be eligible and what taking part would involve.
🅇 This trial is currently recruiting volunteers
If you think you might be eligible, speak to your GP or specialist about this trial before applying.
Status
Recruiting
Phase
NA
Participants
ALL
Age Range
18 Years – 41 Years
About This Trial
This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.
Who Can Join?
Inclusion Criteria: * Over 18 years of age and under 41 * Mild to moderate anxiety and/or depression * Normal or corrected to normal vision Exclusion Criteria: * not taking daily dietary supplement containing >2 mg Vitamin B6 * not taking medication that is a GABA agaonist (our team will check this with you) * not be pregnant * no medical history of epilepsy * no medical history of peripheral neuropathy * not taking the antibiotic Seromycin (prescribed for tuberclosis or urinary tract infection) * no history of brain injury or recent concussion
⚠ Always speak to your doctor before applying to any clinical trial.