Evaluation of Safety, Side Effects, and How the Drug, Inhaled CHF10136, Is Absorbed, Modified and Removed From the Body in Healthy Adults and Adults With Asthma

INCLUSION CRITERIA For PART 1 – SAD * Healthy male or female participant ≥18 and ≤55 years of age * Body mass index (BMI) ≥18 and ≤30 kg/m2 at screening and weight at least 50 kg; * Good physical and mental status, determined via assessment of medical history at screening and physical examination at screening and prior to randomisation; * Spirometry measurements within normal limits at screening and prior to randomisation based on the American Thoracic Society (ATS)/European Respiratory Society (ERS) interpretative strategies for spirometry. The forced expiratory volume in the first second (FEV1) must be >80% of predicted normal value and the FEV1/Forced Vital Capacity (FVC) ratio must be >0.7. * Male and Female participants willing and able to comply with study procedures For PART 2 – MAD * Male or female participants ≥18 and ≤55 years of age at screening * BMI ≥18 and ≤32 kg/m2 at screening…